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[84] Nicotine is a parasympathomimetic stimulant [87] that binds to and activates nicotinic acetylcholine receptors in the brain, [88] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate, endorphins, [89] and several neuropeptides, including proopiomelanocortin-derived α-MSH and adrenocorticotropic hormone
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